The biggest difference between the salt mixes as already basically touched on by everyone is consistency and ratios. Some have higher alk, some have higher Calcium, some higher mag, some more trace elements. They are all good salts for the most part with a particular customer in mind. If Instant Ocean is serving you well in a FOWLR tank with Clownfish then there is little reason to change. A new salt just means a new learning curve and adjustments to your current equipment. If there is something you wish your salt did better at, right out of the bag, then do your research and find a salt that does that better.