I said yes, here is what happened to me:
I had a SPS tank that had been setup for about 3 years. Very good growth, superb color, nothing added for 3 years. I had red bugs since the beginning of the setup, but since I never traded with anyone, and there seemed to be no health issues, I left them. I observed them carefully to check the population size, they seemed to gain, then shrink, back and forth over the 3 years.
Over time, I decided that I needed to give some of my coral frags away. I was throwing away large pieces every few months since they were growing out of the tank, and all my sumps were full. Not wanting to ever pass along a pest, I decided to use the Interceptor in the full tank. Did about 4 treatments over a period of time and eradicated the red bugs (1-2 month period, can not remember now).
After about 3 months I was sure I was pest free, I was going to start giving my frags away, but my growth was severly reduced to the point of almost no growth. Then another month went by and colors started to fade on some, recession in certain areas, etc.
All this time, I am following all my normal routines, testing bi-weekly, continuos water changes, filter replacements, etc. I had two other tanks, not connected, not treated that were still running great (never had red bugs).
After another month the corals were really taking a major hit. Not my montis, nor the slimers, just certain acros, especially the millies. Then I found the egg masses. Treatments began, dips, etc, finally eradication after 6 months. Colors are back, growth back, etc.
Nothing was ever added to this tank in 3 years, no extra fish, no clean up crew, frags from other tanks, etc. My routine stayed exact, I log all filter changes, bi-weekly test,, bulb replacements (same bulbs), all stayed as consistent as possible. Could there have been water issues, defective test kits, bad bulbs - all possibilities that stress is causing an immune breakdown. I don't know.
My only conclusion is there must be some kind of defense mechanism that breaks down when a certain stress point is reached. I have heard of a couple people that moved their tanks, then all of the sudden major outbreak. The worms were alwys there, no doubt, but what triggers the epidemic?