I've long considered mandys one of the easiest to keep (no worries holiday feeding, no diseases, no fighting, no problems)---I just don't lose them. I'm keeping both a mandy and a scooter blenny healthy in a 54, with a 20g fuge.
Re your question, Viodea, the signs are: at minimum1 lb per gallon porous rock in your main tank, a sandbed in both fuge and tank, and a ball of cheato roughly the size of a basketball, with more live rock in the fuge as well as the main tank. Pods generallly come in with the cheato, and will thrive and breed rapidly in this environment. I would add: no sponges, filters, or filter socks in the system. They trap pods. A pod can handily survive a trip through an Iwaki pump (one of the more violent) and make multiple trips through your system. Mine are pumped 15 feet up to the tank, and probably cycle a few dozen times before a fish gets it. As soon as pods appear in the main tank (usually early) and IF you set up such a fuge, then I would think you are ready: the tank has shown it is viable for pods, and your cheato purchase has brought in no few. They will start breeding in your fuge and will keep ahead of the mandy from then on.
You can tell how well a mandy is eating by how many 'hits' or 'pecks' per minute they make at the rock. They should be rewarded several times a minute.