If you aren't part of a larger commercial size shipping label organization you can expect very high cost to send a box the size and weight you are talking about as an overnight. In excess of $100 for shipping alone.
Cost aside. You'd be best served to get a few very large 4mil poly bags, stuff them together for a triple bag. Fill with water, seal vial bag staple or heat seal, and place in a 1.5" foam thermal insulated shipping box. If there's cool weather about, use a 48 hr warmer taped to the inside of the lid with air holes vented directly to the heat pack.
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