Absolutely. I have both soft and stoney corals. I think you do need to pay extra attention to where you place what, though. Try to keep your stoney corals upstream from your soft corals. Also do a little research into the toxicity of some of the soft corals. Some are worse than others. I also run carbon 24/7 just to be safe, but I think most of the soft corals really only release significant toxins if they feel threatened. So far, I have a candy cane, open brain, hammer, favites, finger leather, cabbage leather, xenia and mushrooms. They're all growing and getting along quite well. I know there are many others who have kept mixed tanks with just as much success.