First, lets clear up what the pump flow will be for your tank. Are you saying that the pump puts out 350 gph at 8' of head preasure? Usually, the pump makers will give you pump output at 0' of head.
350gph in a 65 gallon tank is probably manageable, but you will need to distribute the flow over several return outlets so you don't have excessive flow in some parts of the tank.
I would experiment with the returns before putting seahorses in the tank.
For what its worth, I had 750gph flow in my 65 gallon reef and it was not enough flow for corals. I needed to concentrate the flow in 1/2 of the tank to get decent flow for corals.
In general, you want to give your seahorses a mix of moderate flow and low flow areas so that they can move back and forth between the two.
If you want to be safe, you can go with lower oveall flow as well. You don't need a lot of flow for seahorses.
Fred