No noticeable difference too. Stopped using, after finishing the first bottle. It seems, that if it pulls out nitrogenous compounds, it does it very slowly and in very small quantities.
Ca and alkalinity: if your test kits are good, then you may check if the detritus accumulates in the tank somewhere, without being removed. Redirecting flow or cleaning this part may help partially with alkalinity. But 2-3 times a week dosing still may be necessary.
Is you canister filter reasonably clean after 3 days of use? I had to clean mine every 3 days, or water started fouling - unlike protein skimmer, that removes waste from circulation, and micron socks, that can be changed every day or two, canister filter recirculated water through the debris, collected on filter media. Nothing new to you in this, of course.
Ca - if you have high calcium consumption in your tank, not precipitation, than just dose Ca, it's not difficult, just part of routine, together with water top-offs. This should be not related to proteins.
