<a href=showthread.php?s=&postid=14290473#post14290473 target=_blank>Originally posted</a> by xJake
Basically salt mixes contain three major ingredients -in terms of what you need to worry about in this scenario. Sodium chloride (obviously), calcium chloride, and sodium carbonate (along with several other "buffer" salts; which behave similarly) make up the large majority of our artificial salt. When this mix is exposed to moisture (water), the bonds between the molecules of calcium, sodium, chloride, and carbonate are all broken and bond with the water molecules instead of with each other. When this water evaporates, the separated molecules don't simply go back to being their original salts. Instead, the calcium and carbonate molecules bond to form calcium carbonate, a.k.a. coral skeleton, aragonite, or limestone (which has extremely low solubility in water), and sodium chloride (salt).
So, where does this leave you? Essentially, when you spill/drip/splash/etc. water into your salt mix, the water quickly evaporates and leaves you with a nice mix of powdered aragonite and table salt - completely useless for making chemically-balanced artificial seawater.
The lesson: Keep your salt mix away from moisture, or you're basically wasting your money (and causing yourself a lot of headaches).