Methylene blue can also be used to reverse nitrite toxicity in fish. If the gills ever look brown, "brown blood disease", from being bound to nitrite instead of oxygen, methylene blue can swap in oxygen. If a tank doesn't cycle well or if the fish has been in a bag or bucket for too long, methylene blue may help the fish breath easier. Nitrite has a similar binding mechanism to hemoglobin as cyanide. Cyanide poisoning is actually treated with methylene blue in humans but I don't know if anyone has looked at the effect it can have on fish. I'd guess when fish are caught with cyanide far away, like in the pacific islands, and live through the whole chain of delivery, they probably die of another effect of cyanide like liver or kidney failure and the buildup of internal toxins. Whoa i got off topic but if anyone has input, please post.