Good luck! Increasing Cu to about .30-..40 ppm over several days is the way to go, IMO. SeaChem (Mfg of Cupramine) is fine with this lower level and I think they are going to re-label the bottle. I like to get fish eating before adding Cu,if possible. If eating fish suddenly stop, that is the 1st indication of Cu intolerance. If this should happen, reduce Cu with Cuprisorb, carbon, or WCs and gradually go up again when fish start eating again. This is rare; IME, almost all fish tolerate Cu very well; especially if increased very slowly. Here's some good poop on Cupramine, the FAQ are vital info. SeaChem also has great tech support and I wouldn't hesitate to call them with questions,
http://www.seachem.com/Products/product_pages/Cupramine.html