They say you can never have too much flow, but depending on the placement of your pumps and what kind of flow rate and sequence you have them set at. I have 2 x 6100 and 2 x 6055 in my 180. The only reason for the extra 6055's was due to the amount of rock and groth of corals, just trying to hit the dead spots. I couldn't imagin 2 x 6100 wide open in a 4' tank without it blowing your sand bed off the bottom.