I'm probably going to get flamed by all the substrate purists here like AL, but here's my own small experience like it or not.
My big tank originally came with a mix of large FW gravel (it was a FW tank at one time), CC, play sand and aragonite reef sand.
I added some bags of fine white dry sand on top to give it a nice "clean" appearance when I setup it back up after to move.
For the first couple of years it never had any unusual algae problems, and the sand never "sifted" to the bottom exposing the gravel and CC like everyone said it would.
The only time I ever saw the gravel was when the big Gobies would dig down more than 2" in the same spot.
Even then the gravel always got covered back up again with the regular flow from the powerheads and as they moved on to work other parts of the tank.
A few months ago the wife decided it was time to rearrange the living room so the big tank got moved 10' away to a different wall.
Of course this was the same situation as moving it across town... complete and total breakdown and removal of all water, sand, rock, fish corals, etc.
So I took the opportunity to rinse all the builtup detrius, and run the substrate thru a colander to remove everything larger than the CC.
Then I added a few more bags of fresh CC on the bottom layer, and topped it all off with the newly sifted sand mixture and several more new bags of pink reef aragonite and fine white reef sand.
In my recent researching here on remote DSBs I stumbled across a lot of people who have been using plain old silica sand from Home Depot and have had no problems.
I've also read up from several people's successful experiences with using sand from the beach which is also just plain silica sand like the kind found at HD and Lowes' too.
As a matter of fact, last night I bought several buckets and bags of playsand at HD and will be setting up a few remote DSBs in the next week or two to give it a try.
Of course, I'm no chemistry or biology expert (or really even close to being an expert on anything in this hobby) so take my experience and opinions for what they're worth... not much.