I have an acrylic sump on my 300 gallon with no problems. I recently used a 29 gallon aquarium for a sump on my 70 gallon. I drilled the side panel and installed a 1 1/2 inch bulkhead for a genX pcx 40 external pump. The pump makes the entire sump vibrat, generating this annoying humming noise. I would imagine a bigger glass tank would have thicked wall which would be able to absorb and dampen the vibration but, IMO, acrylic is much quieter.