The location you will be working in is important - also being from the midwest, I did not anticipate how much the geography of the area affects traffic patterns. In Detroit, traveling 20-30 miles to get somewhere was no big deal, here having to cross a bridge makes any trip a PITA - This fact has separated me from a large number of jobs as I did not anticipate the travel time to get to places that are relatively nearby.
Most of the great stores I've heard of are on the east side of the bay, but most of the fun is on the west side, it seems.
regarding living in paradise, make sure you are prepared for our summers, as they can be just as long and bad as midwest winters. 95F and 95% humidity for 9 months, thunderstorms every afternoon for months, etc. I personally prefer it to full-time winter, but it is something to keep in mind if hot, humid weather bothers you or your family.