I have had a mixed reef, SPS dominated but with a good representation of softies and LPS as well as some NPS. Had it for 3 years now. Softies and SPS represent the two opposite extremes in needs, with LPS somewhere in the middle. The key is finding a happy medium where their requirements overlap. Finding and maintaining this happy medium is the challenge in sustaining a mixed reef for a long period.
Chemical warfare among coral is exaggerated. I have several species of Sinularia, softies that reportedly secrete toxins that will melt SPS. Keeping a good overall flow with judicious use of GAC and appropriate coral placement will solve that problem.
There are three main factors to consider: Lighting, flow, and nutrient levels. All other factors like ideal water parameters are pretty much universal among the tropical coral types. Finding the correct lighting and flow for the appropriate coral type is relatively easy. It's all about placement in the tank. Place your equipment and set up the rockscape so that you have a range of areas that have high flow/high light to low flow/low light, and place your coral accordingly. Finding the nutrient level where everyone is happy is THE challenge, IMO. Not only is finding that level difficult, the tank itself keeps changing. In the first year of my tank, nutrient levels were relatively higher, so the softies and LPS thrived, SPS were so-so. As the tank matured, the biofiltration and the refugium matured as well, and nutrient levels start to drop. The tank is about to have it's third birthday, and the SPS have been growing like gangbusters and the softies now only so-so. Over the last 6 weeks I have been dumping all kinds of food into the tank, have decreased my water changes, and even considered taking the skimmer off line. So far, the softies seem to be coming on strong again, with no visible decrease in SPS growth. We'll see.
HTH!!