I had issues. I used both at the printed dosage. I lost several cowry snails, a royal gramma, and a yellow tang on the second day. Everyone else in the tank was breathing heavy. Did a massive water change and restarted my skimmer. Problem ended. I suspect that oxygen was being sucked out of the system. I would be cautious on dosage if both are used in combination and maybe hook up an air pump. (skimmer overflows constantly)
Tim
