It is safe to a point.It will kill any worms in your tank ie: fan worms and bristle worms.If you have a big population this could cause issues for you.It will also cause some discoloration in some sps and some like my ora birds nest was not happy for a few days.Also you have to turn off your skimmer and carbon while treating.I had clams in the tank and while i could tell it was also affected a bit it was fine.I have no anemones in my tank so i cant tell you how it would affect them.
FYI, prazipro did not kill my bristle worms or the small little fan worms that grow on live rock. I don't have any big fan worms so don't know about those but I do have a lot of little worms and little fan worms and it didn't bother those.
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