The easiest way is with a couple of cheap 24hr timers that you can buy at Wal-Mart, HD, or Lowe's.
For a 75gal you may wish to have two powerheads in the center of the tank and pointing straight ahead or at 45 degrees outward that remain on 24/7.
Then one in each back corner but on the timers. Direct them at 45 degrees inward toward the front center which will cross current with the two centered back.
Mix the timers up so that they go on and off at different intervals all throughout the cycle.
Sometimes both timers are on and other times they're opposed.
This will keep the water currents moving in multiple directions and cut out any dead spots that can trap detritus and build up excess nutrients.
Ed