Although ozone treatment does affect organic contaminants so that they are better suited for skimming, I have not heard that ozone will totally remove ammonia or nitrites from your water.
So, if for any reason your bio-filter does not function properly, you will be doing water changes anyway.
Regarding hyposalinity and ozone. . .During hyposalinity you will have a problem trying to stabilize the pH in the right area. The use of ozone can add a complication to this effort. I can see little value in the use of ozone in a QT.
During hyposalinity, the fish are finding it easier to breath and easier to 'live.' The introduction of ozone isn't going to lessen their stress as far as I can see.
Let us know how it turns out, if you pursue this course.
That size tank should be fine for those sizes of fish you plan to QT. Keep in mind about your intentions to quarantine different fishes together. If one is sick, then you will have to treat both.
For instance, tangs are notorious for having either Marine Ich or Marine Velvet or both. Anemonefish are notorious for having Brooklynella. What are you going to have to do during the QT of both these fishes if they break out with their respective and anticipated diseases? You have to treat them both for everything. This is not my preference.
I would for instance decide what fish are the most peaceful community fish and then QT them together if they are likely to be similar in infection.
