I ran ozone on my 65 for a while. The water was noticeably clearer and skimmate dropped radically. However, I also noticed the ozone smell in the utility room and my kid's rooms were directly above that so I discontinued the use.
It may have benefits but I don't know that it would be worth the possible health risk.
With the units for home aquarium use there is little to no health hazard. Ozone has a very short half-life. For those of you that don't know what a half-life is: it's the period of time it takes for half a given sample of an isotope to deteriorate into a different isotope. It's only a few seconds for ozone in seawater. When dosing ozone within the recommended range it shouldn't build up into dangerous levels in the ambient air. Nevertheless caution should be taken to avoid buildup of amounts of ozone in the aquarium and the ambient air. For some information here are some articles: