In a word: no. Unless it's spilling out of the tank. I'd like to know how you crammed that much in there though, unless it's really, really dense rock. I had about 200 lbs in my 155 and that more or less filled it up.
The only problem that I know of with a lot of rock is that there are more places for detritus and stuff to hang around in. Oh, and if you ever have to get a fish out your kind of scwd.
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