It is the vaccum and anerobic enviroment that "supposidly" keeps the microbes in the sand in a state that can handle the heat / cold ect... of being packaged. So if they are now exposed to air they theoretically could have died.
IMO there is really no such thing as "LIVE " sand. I beleive pretty much everytbing is dead anyway, and the sand just helps to produce a great NO2-3 cycle as the dead organizms produce a good ammonia reaction when placed in warm saltwater and start to decay producing a stronger nitrifying affect in the end. I would use it and expect the same results.
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