Efficiency is a fun exercise. When you look at efficiency you also need to consider total energy use over a period of time. That is if the goal is to reduce electrical consumption. Multiple points of heat end up using less total electricity than a single point of heat. A single point will heat the water near it fast, but because the higher the temp differential the greater will be the cooling, the water cools faster as it moves away from the heater. Four 100 watt heaters spaced apart can use less electricity than a single 400 watt heater. The reason is simple, cooling differential. The higher temp from the 400 watt heater will exhibit more cooling from the temp differential than the 4-100 watt heaters. As the water moves away from the 400 watt heater it has to travel through the entire system before it is heated again. With the 4-100 watt heaters there is less heat loss before the water encounters another source of heat, and with less temp differential the cooling is also less.
How much of a difference does it make? Not a lot in reality but the real benefit from multiple smaller heat sources is disaster prevention. If a heater malfunctions and the thermostat sticks in the on position, it is more difficult for the 100 watt heater to overheat the tank than if the single 400 watt heater stuck in the on position. Given a choice, it is usually better to use multiple smaller heart sources than one large one, at least in aquarium pumps that have a higher than acceptable failure rate. The difference in energy usage may be measurable, but also negligible as well.
How much of a difference does it make? Not a lot in reality but the real benefit from multiple smaller heat sources is disaster prevention. If a heater malfunctions and the thermostat sticks in the on position, it is more difficult for the 100 watt heater to overheat the tank than if the single 400 watt heater stuck in the on position. Given a choice, it is usually better to use multiple smaller heart sources than one large one, at least in aquarium pumps that have a higher than acceptable failure rate. The difference in energy usage may be measurable, but also negligible as well.