This is rich in vitamins, I would not dose more than 2-3 times per week. Keep an eye on glass algae/film, and dose 1 drop per 27 gallons. I used it once per week on my 120 gallon reef, with large colonies. I used only 2 drops on food, I did see marked improvement in fish color and health. I suspect the corals will also have use for these vitamins and the waste of fish. Like anything you dose, dose and observe, start 1/2 dose to break in the product, and test nutrient levels. The product is designed to dose macro or saturated into thawing frozen foods. I use LRS Reef Frenzy FWIW, which already has natural vitamins and probiotics. Cheers