Like I tell people daily, "reef safe" is a poor term. I have a "reef safe" fish that has all but destroyed my home tank. Ever heard of a Hippo killing a clam, eating xenia, candy coral, anthelia, and lastly blastomusa? You have now. Every fish "can" go crazy and start destroying you reef IMO, you just have to keep an eye on them. I know people who have angels in reefs with no problem at all, but I won't try it. On second thought maybe I should have, Im sure a flame angel could not have caused as much damage as this flippin hippo.