Yes, I've done it. Just like you've said, it does require very regular water changes. I was doing 10-20% water changes 3-4x per week with a juvenile maroon clownfish in a 10g tank. My ammonia, nitrites and nitrates all stayed at undetectable levels, so that many water changes may not have been necessary. I also made sure to vacuum the bottom of the tank during each water change. There are plenty of medications that will kill your biological filtration anyway.