Having as light of a bio-load as I do in my tanks, I have often thought of putting mine on a timer and not running them for about 8 hours per night. I've started to take notice of a lot more people thinking about running this way.
I would tend to believe that theoretically it would work, but only if you're actually "over skimming" enough that your skimmer is able to process all of your water in the shorter amount of time and you have enough flow in all parts of your tank that stuff that isn't skimmed out right away does not settle and begin to break down.
Since I've dramatically increased flow in my 90 and only currently have 1 fish in there, I've definitely thought about giving this a go. I'd love to see other opinions, links, etc.