If you use the search function on the zoanthid forum, you'll see a lot of the people who had reactions got squirted in the eye and/or mouth. So eye protection and I've read more and more people use gloves. Some for the toxin and some for the bristle worms that can pop out of a rock when you vibrate it with a saw!!!
The only thing i would worry about are your eyes. If it squirts in your eyes then you are in for some pain. I mess with palys all the time without gloves with no problems just make sure you don't have any cuts on you. I first take a razor blade and cut along the runners where i want to frag then i take the dremel and cut through the rock. Pretty easy
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