I think you could definitely give it a try with regular water changes. Part of it depend on what frags you are trying to mix in the tank. I had a skimmerless system for quite some time with all softies and a few LPS that did ok for quite awhile, but I didn't see a lot of growth till I moved them to my 210 display with 3X250 halides plus a couple hundred watts of actnics, and a MRC2 skimmer. That may have been due to some lower wattage lighting in the skimmerless tank though. Some leathers and SPS are not friendly to one another. You will find other frags like zenia, fox, shrooms, or gonipora that thrive in a skimmerless system. Bubbles also seem to do quite well but they like to eat fish food. Other will argue that a skimmer may remove good stuff as well and I can definitely see that point. I think a lot will depend on what you want to grow. Will you have to target feed with meaty foods? What do you want to grow?
Lisa