there is no issue drilling holes in any thickness of glass, other then breaking the glass while doing it...the glass will be just as strong after the holes as it was before if the plumbing is properly supported...
i have drilled tens with a 2 and three holes no problems, i have drilled my old twenty while running for two holes no issues...
be very careful grinding the holes, go slow, support the glass and the drill properly and all will be fine.
i would clamp a piece of wood to either side of the glass, essentially sandwiching the glass in planks of wood...which ever side your grinding from should have a hole (square or round) of the appropriate size to fit the diamond bit. i prefer square holes since they hold more water then a round hole will.