Sometimes they get a Great shipment in!
Often not..
It's a nice little old family style pet store (not a lot of them left)
It's a mixed pet store.
The building is old and dirty in some spots.
But the animals are most often healthy and cared for properly.
Fish are usually very good quality.
They like the Marine hobby. But with everything else they do running an all around pet store.. it's hard to do. The owner (and I've been a customer for 30 years) has told me it's too expensive to do much with the Corals. So, they often don't have any. They do get a small but nice selection of Marine fish & other invertabrates.
Long standing customers can get special orders from them. He has an affinity for rare and special Giant size fish. Rare Cichlids, Freshwater Arapaima and Marine Nurse Sharks have been sold there. Like once or twice a year. But they won't do it for most people as tank size is definitely important.
If it's not out of your way, it's an "ok" stop. Once in a while there is even a couple nice rare marine fish.
I would just call Neptunes ahead though and see when & if they are getting a saltwater shipment in during the week you plan on going to your Buffalo trip. If so, you could stop in on the way. If they are not getting one, then it's not worth it and don't bother. You'd be disapointed in that case.

One highlight I could add is: This coming up Saturday 11/15/2012 is their annual customer appreciation Christmas/Holiday party.
They have some specials/sale on some in store stuff... But if nothing else- the highlight is FREE FOOD. Plenty of it.
ALL Day long. Ordered and Homemade stuff. Chili, Pizza, Meatballs, sandwhichs, cookies, cupcakes, cake, more and Drinks. All Free for customers.
(last year '11 for the same party they also had a wildlife rehab expert present and exotic reptile show . Don't know if they they'll have it again this year)