I would not recommend it, the Osmolator nano uses the same pump as the osmolator but it is only given 7V and it is basically running at its lowest possible speed and pumping volume. It may work, but it may not depending on head pressure and top off volume needs. The Osmo Nano is really a bare bones base model top off intended just for small tanks, on anything bigger than about 50 gallons, or where more features are desired, like attachment to a kalkwasser reactor, the 3155 will be the way to go.