I run a large external reef octopus skimmer on my 500g tank and have it draining 9-10ft away
, and I do experience some issues from the back pressure. The level inside the skimmer isn't always constant; it's not a regular thing, but occasionally the water level in the skimmer will drop about 6 inches and stay that way for 5-20 minutes.. Totally random, then go back to normal for a while. Seems to do this a few times, then it will go away for a while. Overall it skims ok, but not great because of this.
However, my downward slope is fairly gradual, so if you try it, maybe raise the skimmer up more so you have a quicker gravity drain, and that might help out. I have mine around 18" off the floor.
Good luck!