I use the pre-skimmer box on my Remora Pro with a Mag 3 pump. The prefilter on the pump doesn't fit in the box, so you can't use it. I've only had one fatality because of it - a cucumber crawled into it while it was off then got shredded. I used to turn the skimmer off and on periodically, but I mostly leave it on now.
Because the box is attached to the pump itself, you have to make sure the pump hose is securely fastened to the pump and the skimmer. For some reason, AquaC only supplies you with one hose clip. I had the same problem as Fuzzy's aunt. The weight of the box pulled the hose off of the skimmer sending a fountain all over my hardwood floor one night. However, the problem is easily solved with another hose clamp to hold the hose at both ends. Plastic hose clamps like the one that comes with the Remora are available at most small hardware stores, though not at HomeDepots or Lowes (in my experience).
You will also have the problem that Clwnnrnd mentioned about keeping the water level just right. I don't have a sump either, so I have to add water weekly using a jug above the tank. I will typically get the water level too high for the preskimmer box to skim the surface, but within a day or 2 (about the tie a surface scum starts to build, the water level goes down the point that it starts skimming the surface again.
One problem that I had was that the box was almost flat against the back wall of the tank, restricting flow into the box from the back to the point that the pump goes dry. To rectify this, I used aquarium-grade clear silicone caulk to make four small mounds on the back of the box. The mounds are about 1/4 inch high and hold the box away from the back wall enough for good water flow. With this minor modification, the box works fine.
The box is big and unattractive, but a little coralline algae helps cover it. I'm not so sure it doesn't take up almost as much room as many built-in overflows. I take the skimmer out of the tank about twice a year for a good cleaning and the box makes it much more difficult because the pump is so crammed into it. I had to have it though. I tried everything else to get rid of surface scum and nothing worked, so I'm very pleased with the box overall. And I also get lot of little sponges, including miniature vase sponges, growing on the wall beneath it, which is kind of neat.