How big is your tank? Just wondering, 10-20lb on a small tank could be an issue, but on a larger tank probably not like you said.
I think if you take it slow you may not even have diatoms.
edit:
If that's 10-20lbs of sand in total in your tank with 1" or less sandbed, I can assume it's probably a smaller system. I would be careful, small changes are the best route to success. Just my two cents..