I vacuum 1/4 of the sand during a water change and do a different section each time. I have about 2 inches of sand but I think if you have a deep sand bed you don't want to disturb it.
Are you relying on the SB for bio filtration? if not ( you have a sump full of rock ) vacuum away. if so just do a section at a time every water change as said before.
I have a deep sand bed . I've read enough times not too disturb it because deeply. As far as dirty sand if you are talking about the surface gunk...i finally purchased a worthy cleanup crew for my size total volume water and my sand now and rocks are spotless . Good cleanup crew saved me and my sanity. My sand is super white like a beach, now. Only thing I clean is glass occasionally .
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