Although popeye is oftentimes caused by physical wounds, the popeye can still get much worse resulting in complete loss of the eye. In 2 instances, I had fish with popeye end up losing one eye each because of delayed treatement. I now take popeye very seriously. I closely monitor the fish and if symptoms improve, then I just leave him alone. However, if symptoms worsen, then I will move him into a QT and begin dosing with an antibiotic in the water and feed antibiotic food immediately.
I liken popeye to humans getting cuts on their hands. 95%+ of the times, the wounds just heal by themselves and we forget about it. However, sometimes the wound will get infected and swell like crazy. Then you would need to see the doctor and start taking oral antibiotics, an anti-inflammatory a painkiller and possibly and antibiotic shot. If you don't get treatement and allow the infection to get worse, then it can become gangrene and you will need to get the hand amputated. Obviously this doesn't happen often anymore because we would get treatment before things got worse.