There can be some drawback. On an LPS/Softy tank, you aren't going to need to suck every minutia of organic from the water. Most softies actually seem to like non-skimmed tanks, and LPS don't seem to care so long as you target feed the ones that will eat sometimes.
The nice thing about a BIG skimmer is that you can always dial it down and skim a bit drier. If it's in your budget to get such a massive skimmer, go for it.
Just keep an eye on your corals. Some corals, like Xenia, can do poorly in a low nutrient tank. My tank has a cheezy DIY pvc skimmer driven by an air pump, and my xenia can only barely survive, while LPS are growing fine (b/c they can be target fed).