I have no where near that large of a tank, but I have a 180 and had a 110 previously. I went from my 50 to the 180. I was used to the added equipment cost(one bigger skimmer, additional real estate of lighting, supplies), but, with this tank I have learned about water changes heavily..
The big thing with larger tanks is, that they really do run themselves with a few key points.. First, that large of a tank, your going to really "need"to run your ro/Di from the basement.. Simple task, just run the product line up through the floor to the holding container for your top off. And use a booster pump.. It's that simple. Iran 35 feet with my 110. You really, really don't want to have to lug buckets for top off..
Water changes should be similarly simple. Your basically going to be drilling a couple holes in the floor. Then running the tubing from your central location(ro/di, water changer, etc) to the tank.. It's honestly not complicated at all.. I drilled three 2" holes for the 110 and had plenty of space after setting things up.. Mine was in the living room also. I had the sump under the tank, but I still had the Di water system and mixed up my saltwater(by hand) in the basement.
Then I had a little pump to pump the new water up.. I had a valve on the out line(i kept it simple, but had planned on automating it later) for draining for water changes.. I turned the valve, filled the tank with old water, shut off the valve, turned on the pump, and pumped up the mixed saltwater. The more maintenance based things in one location the better.. At least for me at first..
But equipment wise, just be ready to spend up front, say for a skimmer, because the price jumps.. Things like that and two part, etc, need to be considered and taken into account.. This tank I spent double on my skimmer than the max I had ever spent on one. And I'm not complaining at all! Because a big tank is the way to go if you can! No doubt about that!
For me, the cost is worth it, in the different life that you can keep to completion.. But it's easier are the initial setup for sure with a bigger tank than a smaller one..
Just have all your ducks in a row before you put water in it..