first question is did you buy that reactor from joe??? it looks really similar to his reactor.
second thing you may want to consider is going deeper with your tank. you can get acrylic sheets up to 8 ft x 6 ft with out paying more per square foot for the acrylic. once you go over that size the sheets get crazy with the prices. the depth of the tank really makes the tank alot more interesting. depth gives you alot more sand bed areas and gives your corals alot more room to grow out.
next you might want to mach up the room in your garage floor with tape so you have a good idea of walking area and places to put things like test kits, additives, all the mics reactors, a small quarantine tank/frag system, and work counter with sink. these are things that would make a good fish room great. i have had the opertuninty to see and work in a few fish rooms and none of them ever had enough room once everthing was in the room and the system was running. if you can spare the room you might consider making the room 20 ft wide and at least 12 ft deep. you will have room around the tank on the sides to work in the tank and place equiptment. you might want o make the stand alot bigger than the tank and have walkways around 3 of the 4 sides of the tank. this would make maintaince in the tank alot easier. then plan for a deticated floor drain with a sloped floor so all the dripped water goes down the drain. if you can do it have the celings really tall. this would give you the ability to raise the lights straight up instead of going back with them. it would also give you the ability to have surge tanks at each end of the tank. you can also stack up storge tanks on a stand and have alot more lower floor space for small items like ca reactors and kalk dosers.
next you might consider external overflows on each end of the tank and leave the back completly open for maintenance. run a sub pannel with breakers into the room so you dont run out of outlets. and use an extra large air exchanger that is dedicated just for the fish room. this can be mounted in the rafters. if you use fiberglas reinforced pannels for the walls it will seal the room off from the rest of the house and make rot and mold laot less likely.
if you put 2 doors in the room it would take aray wall space in the room and you might want to make the room biger to compinsate for that loss of wall space. its a good idea but you need to weigh it out to see which is more important to you.
take all of this as me giving you ideas. its your system and im just trying to give you options and ideas you may not have thought about.