Well, that would likely provide the healthiest environment for them; they wouldnt have to stress out over all those other softies in the tank giving off chemicals in an effort to out-compete the SPS. That being said, Many people have mixed reefs with great success- good carbon usage, heavy protein skimming, regular water changes, etc will all dillute the toxic soup (all of which are procedures you should be doing in a tank trying to grow SPS anyhow).