For cupramine, the instructions may be a bit fuzzy. Generally folks here feel that the 0.5mg/l dose they recommend is too high and too aggressive. Try dosing at 0.35-0.40 and keep it there for the 4 week period. Also ramp up the dose slowly over 5-7 days to give the fish time to acclimate better.
Cupramine Dosing Formula / Calculator
(.381) * (strength of dose) * (gallons being treated) = mL of Cupramine to dose
Example: (.381) * (.5mg/L) * (10.5 gallons) = 2mL of Cupramine to dose
It is advised by Cupramine that you bring up the levels slowly & not dose all at once.
I think this formula takes some of the guess work out of trying to figure out how much to dose. Especially when using a syringe.