Yes,
Many have success running, but it will bring nutrients down quickly, and could harm your corals if you use too much or too high of flow rate. This media is excellent in systems that have large fish populations, as the zeolites help to reduce ammonia quickly, therefore removing these toxins before the cause harm to animals in the tank. Zeolites also are used to remove other toxins, they have been used for years in Aquatics, and some use as air fresheners as they remove pollutants from the air as well. I would consider them a means of ammonia removal, which expedites breakdown in the nitrification cycle, therefore the nutrients can fall quickly, especially nitrates. Phosphates may still need help, depending on your bioload, for this, some actually stack in one single reactor, ZeoMix(on bottom of up flow reactor), then place AF Carbon on top of that, then a thin sponge, then AF Phosphate Minus on top of that. The flow rate is determined by a gentle tumble of Phosphate Minus. The Zeo Mix does not need shaking, that is how this is possible. Change every 4-6 weeks depending on test results.
Cheers,