Since mushrooms are so slimy, I would think that that would effect the growth of your zoo's. You could run some carbon or do water changes but I have heard that leather coral can kill zoo colonies if left unchecked. Largly alleopathic due to the nature of that species!
5" should be plenty of room especially if you have a decent amount of flow in there. i've had zoas grow completely around the base of a leather before.
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