Jeremy,
I believe that AlgaeFix should be used as a last resort to control algae, especially if you have a lot of expensive organisms in your tank. I do not have expensive sps in my tank.
There have been some hobbyists who have posted in this thread that have lost some coral and other organisms while dosing AlgaeFix. I dosed AlgaeFix for quite an extended period of time without loosing any coral. AlgaeFix does not work well on all algal species.
From my readings AlgaeFix kills algae in simple terms by causing a hole in their cell membrane allowing the contents of the cell to leak out. Many algae such as the siphoning algae, have superior methods of repairing their cell membrane and are not effected as much. The chemical ingredient in AlgaeFix, at least at higher concentrations, will indiscriminately kill all micro-organisms. Some of my concerns while using AlgaeFix, would be any effects that it may have on the symbiotic algae within coral tissues. These symbiotic algae within the coral tissues are somewhat protected. AlgaeFix does brake down quickly, with in 24 hrs. I would assume that AlgaeFix may have effects on bacteria and other micro-organisms in a reef system. The issues at hand while using AlgaeFix are very complex and many unknown possibilities exist. In conclusion, AlgaeFix is a product that is potentially dangerous in a reef system.
For those hobbyists who do decide to try AlgaeFix, there is a concern regarding the dead and dieing algae once AlgaeFix kills algae in a reef system. These dead and dieing algae will be broken down by other organisms (bacteria & cyano) and their contents will be released into the water column, which may cause blooms and lack of oxygen. Is is important to remove the dead & dieing algae as well as the living algae.
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FWIW, this is what I normally post regarding fighting algae:
There are a lot of hobbyists in your same position. Reducing your nitrate and phosphate levels to a zero reading will help in getting rid of many type of algae pests. IME, reducing nitrate and phosphate levels too low can kill or cause problems for many types of coral. Running GAC & GFO will all help in reducing the growth of these type of pests. In many cases they will not eradicate the pest. Vodka dosing will help reduce the nitrate and phosphate levels also, but will not necessarily eradicate the pest either.
A common problem is being able to identify your pest to a catagory correctly: true algae, cyano, dino, bacteria & other assorted pests that look similar. In many cases a micro look at your pest is best to properly ID it to one of these catagories.
IMHO, if you are faced with an algal type pest problem, it is best to implement an algae pest control program strategy:
1) Wet skimming with a good quality skimmer. Clean your skimmer cup at least once per week.
2) Reduce your nitrates and phosphates to a zero reading using the hobby grade test kits. See Randy's articles regarding this:
Phosphate and the Reef Aquarium
http://reefkeeping.com/issues/2006-09/rhf/index.php
Nitrate in the Reef Aquarium
http://www.advancedaquarist.com/issues/august2003/chem.htm
3) Proper lighting. I find that the higher wavelength bulbs are less conducive to algae growth. I now run 20,000 K bulbs from using 10,000 K bulbs.
4) Proper day length is a good thing also. I would not run your lights for more than 12 hrs total. Keep in mind that light entering from a window nearby is added to this figure.
5) Running GAC is a good practice in my book. It will help reduce the total dissolved organic carbons in your tank water and this is a food source.
6) Proper 30% per month total water changes will help export the DOC as well as some of the pests in the water column. It will help maintain the micro-nutrients as well.
7) Physical removal of the pest by hand, scrubbing and siphoning is important as well. If the amount of pest in your aquarium is overwhelming, perhaps dealing with one section at a time is a better idea.
8) Proper water circulation in your tank to prevent dead zones. When dealing with cyanobacteria pests increasing the flow where it grows seems to help.
9) Use RODI water for all top-off, salt mixing, additive mixes... etc.
10) Dosing iron may have benefits for macro-algae, but if you are experiencing algae pest problems than I would stop dosing it as it can add to the problem in many cases.
11) If you are dosing other supplements such as vitamins, amino acids, or others that contain a mix of supplements other than the basic alk., calcium and magnesium, I would stop these until you gain control of your pest. This includes many of the store bought products with unknown ingredients. Dosing Vodka or sugar to reduce your nitrates and phosphates would be an exception in my opinion.
12) Proper feeding habits. This can be the number one problem when trying to reduce your nitrate and phosphate levels. Use low phosphate fish foods.
13) IMHO, lighted refugiums may be a problem when trying to deal with an algae type pest problem. They are wonderful when it comes to reducing nitrates and phosphates. However, the light over most refugiums is conducive to the microalgae type pests. If the refugium becomes infested with a microalgae pest, I would clean it throughly of all pests as best as possible, remove the macro and turn off the lights until you gain control of your pest. Re-using the same macroalgae later may serve as a source for re-infestation of your pest.
14) Adding fish and other creatures that will eat your algae pest will help.
15) There are other items that can be added to this list if others care too share and some of the items listed may be disputed.
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If after you have tried all these procedures and you are still loosing the battle, I would recommend that you initiate the use of AlgaeFix Marine based on the reports I have seen in this thread:
http://www.reefcentral.com/forums/showthread.php?p=16056708#post16056708
I hate to see anyone give up on this hobby due to algae type pest problems.