On the nopox I've never seen or heard of a rapid drop in P04 using any carbon source ( nopox is just vodka, vinegar and some water in a certain ratio). So in your case if your hunch is correct it may fuel a larger bloom in slime way before it starts to get better causing you to make more unneeded changes.
Make sure to test nitrates frequently while starting and getting to your maintenance dose to make sure you don't strip out all the nitrate rendering dosing useless. Just monitor your phosphate and remove when/if needed. I'm sure you can find hundreds of threads and remarks of nopox not removing phosphate ( it will it just needs time Ime and tanks). Your numbers where they sit are almost perfect so I hope your not striving for the 0/0 approach.
The well water and stating never having more than 5tds after the di stage is what has me wondering. I'm on municipal water with really low tds so im spoiled but I work for a water municipality and our supply Wells have all sorts of issues with nitrates, toxins, ammonia, silicates etc.. So if your leaving some of that in your make up water it's making it straight to your tank.
Spectrapure and other manufacturers makes specific filters for a lot of things like lead, silicates, nitrates, heavy metals etc. I personally would send off my water to get professionally tested and build my RODI around it by talking with them. A Booster pump is key as well to get the most out of your system, if your getting 50psi I think your under the stated "ideal" working pressure of most tfc membranes. Even my pressure gauge on my unit has the green ( best working pressure) start @ 60 psi.
My only thoughts are your on a well with crazy tds, so what is that tds? Is your rodi equipped to remove it? . Running a lower pressure and getting up to 5 tds when most strive for 0 could be a place to start. You may never get 0 TDS but having the correct filters could change the properties of that 5 tds turning the tank into what you want.
From the outside looking in your doing everything right, have great equipment and a solid maintenance schedule. That's what makes me think your source water comes into play. Like I said that's just where I would start and in no way am I saying I'm right, but I would HAVE to know what is in my well and if my filter is capable of removing it.
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