Are you talking about fixing a leak in the tank while there is still stuff in the tank?
I would think even if it did work, it should only be for a very temporary time.
To seal a tank properly you'll need to have it dry and cleaned, making sure to get all the old silicone off.
I tried sealing a tank that had a small leak and the new silicone wasn't curing properly. I found that if you scrape all traces of the old residue off and clean it with alcohol it cures like it's supposed to.