this is the kind of info i was looking for,as i under stand its actual effects on marine ornamentals is not well syuddied. It appears that the food fish industry has done multiple studies on the subject and has mixed rusults. Also as i have read on there is more than one type of beta-glucan and it appears that the 1,3 beta-glucan is the most heavily studied. there is also a 1,6 beta-glucan that has lower positive results as i understand. (the 1,3 and 1,6 refer to the way the glucose molecules are linked) specific to your experience, it seems that once the immune system is already working hard beta-glucan may not have any effect at all. my under standing is that for pathenogens it is best added to the regime of antibiotics, it is mostly said to be preventive. (eg. you notice you have an ick infested fish in your tank beta -glucan may help the other fish from getting infected) thanks for the reply i was hoping to start a conversation that might lead us all some where, pos or neg who knows, but id like to find out.