From what I have understood, bio-balls, bio-wheels feed nitrates back into the system causing algea issues to develop.
If you are doing a reef tank, my recommendation is to go with live sand and live rock as you main filtering medium. Add a good skimmer. Use a sump/refugium setup and all should work well for you.
I have been here for just over a year and started with a HOB filter and a skimmer/live rock and the the such. Since then I have upgraded lighting, added a sump, and now building a refugium to add into my system in a few days...