Yes, it is. Boiwheels are a great place for the bacteria that convert ammonia to nitrite and nitrite to nitrate, but the bacteria that convert nitrate into nitrate gas require anaerobic (low oxygen) conditions such as those in the bottom portion of a DSB or in live rock. Biowheels are great for FW tanks or fish only tnaks, but CAN cause problems in a reef where nitrate buildup is a concern.